Histamine Poisoning after Ingestion of Spoiled Raw Tuna in a Patient Taking Isoniazid.

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Histamine poisoning after ingestion of spoiled raw tuna in a patient taking isoniazid.

An 83-year-old woman taking isoniazid (INH) suddenly developed a headache, palpitations, and skin eruptions with itching while eating raw tuna. The symptoms were compatible with those of histamine intoxication. When given fresh raw tuna to eat, no such reactions were evoked in this patient. The episode was speculated to be due to two conditions; eating spoiled raw tuna and at the same time bein...

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The scombroid poisoning is due to the ingestion of poorly preserved fish (especially tuna, sardines, and mackerel) out of the cold chain. Under the influence of the proliferation of gram negative bacteria that occurs for heating, the histidine content in the muscle of the fish is converted into histamine, by the action of the enzyme histidine decarboxylase. If the histamine is ingested in large...

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A 65-year-old woman presented with the sudden onset of feeling ‘‘hot,’’ accompanied by a diffuse, blanching red rash, conjunctival injection, and one episode of nonbloody diarrhea. It happened suddenly about 90 min after consuming a dinner that included fully cooked tuna. It was also associated with mild diffuse pruritus, and the patient reported feeling restless. The patient reported that her ...

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ژورنال

عنوان ژورنال: Internal Medicine

سال: 1997

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.36.198